Tag: Fibromyalgia

An in-depth guide on Fibromyalgia, covering its symptoms, causes, treatments, and tips for managing this chronic condition effectively.

  • Struggled for the Social Security Disability of Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS)

    Struggled for the Social Security Disability of Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS)

    “Fibromyalgia, Chronic Fatigue Syndrome, and Objective Medical Evidence Requirements …” was the subject of a memorandum from Social Security Deputy Commissioner, Susan M. Daniels, Ph. D., (“the Deputy Commissioner”) to a Social Security administrative law judge (ALJ) in May 1998. This memo has been widely circulated.

    The memo was in response to memoranda from the ALJ to the Deputy Commissioner, to an appeal judge, and to the general counsel for Social Security. The ALJ asserted that fibromyalgia and chronic fatigue syndrome (CFS) are not “medically determinable impairments” under the Social Security Act and urged the Social Security Administration (SSA) to take a definitive position on this question.

    The Deputy Commissioner responded that SSA had taken a position: that fibromyalgia and CFS can be medically determinable impairments under the statute.

    She explained that a specific diagnosis is not necessary to prove a medically determinable impairment, especially where the medical community has not yet agreed on the diagnostic criteria. If there are anatomical, physiological, or psychological abnormalities that can be objectively observed and reported apart from the claimant’s perceptions, a medically determinable impairment is shown even in the absence of a definitive diagnosis.

    The “signs and the findings” required to prove the disability may include symptoms when appropriately reported by a physician or psychologist in a clinical setting.

    CFS is “clinically evaluated, persistent or relapsing chronic fatigue that is of new or definite onset which cannot be explained by another diagnosed physical or mental disorder, or by the result of ongoing exertion” and which “is not substantially alleviated by rest and results in a substantial reduction in previous levels of occupational, educational, social, or personal activities.” It is a systemic disorder whose symptoms and signs may vary in incidence, duration, and severity.

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    Records reflecting ongoing medical assessment and treatment are needed to document objective physical and/or mental findings. SSA will recognize a medically determinable impairment if the records for at least six consecutive months show one or more of the following:

    • low-grade fever;
    • palpably swollen and tender lymph nodes;
    • nonexudative pharyngitis; and/or
    • muscle wasting with no other direct cause identified.

    While there are no specific laboratory findings that definitively document the presence of CFS, findings indicating chronic immune system activation, such as slight elevations in immune complexes, depressed natural killer cell activity, or atypical lymphocytes, may also be included in the evidentiary record of individuals alleging CFS.

    Some CFS sufferers report problems with short-term memory, comprehension, concentration, speech, and/or calculation. Others may exhibit signs of mental or emotional disorders such as anxiety or depression. When documented by mental status examination and/or psychological testing, these findings mark the presence of a medically determinable impairment.

    So, when your patient reports disabling fatigue, your thorough examination – at least looking for the signs noted above, scheduling follow-up visits to monitor persistence, referral (as needed), and comprehensive chart notes on your observations, even if a definitive diagnosis is not possible, will provide the medical documentation needed should this condition become so impairing as to force your patient to apply for Social Security disability benefits.

    Your documentation is critical since symptoms alone cannot be the basis for finding a medically determinable impairment, which is necessary to prove disability under Social Security law.

    The SSA recognizes fibromyalgia as medically determined if the tender points identified by the American College of Rheumatology (ACR) are documented.

    The ACR defines fibromyalgia as “widespread pain in all four quadrants of the body for a minimum duration of 3 months … in at least 11 of the 18 specified tender points which cluster around the neck and shoulder, chest, hip, knee, and elbow regions.”

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    Other typical symptoms which may help prove fibromyalgia if clinically documented over time are irritable bowel syndrome, chronic headaches, temporomandibular joint dysfunction, sleep disorder, severe fatigue, and cognitive dysfunction.

    The Deputy Commissioner acknowledged that policies concerning the adjudication of claims involving impairments like fibromyalgia and CFS needed to be better explained and that policy guidelines were being drafted for that purpose.

    We have noticed that fibromyalgia has been the subject of increasing numbers of articles in medical journals in recent years, including several by Robert M. Bennett, M.D., F.R.C.P., Professor of Medicine and Chairman, Division of Arthritis, and Rheumatic Diseases, Oregon Health Sciences University.

    Recently, a victim of CFS represented by our office had to appeal her Social Security claim all the way to the Federal District Court. There, the Federal judge not only ordered that she be declared disabled and awarded benefits but also penalized the Commissioner of Social Security for unreasonably denying her claim. Our client’s medical record included the types of documentation described in the Deputy Commissioner’s memo.

    The absence of definitive diagnostic criteria and the absence of the usual objective and observable findings make these conditions difficult and frustrating for physicians to identify. However, Social Security will evaluate these on an individual basis. Severe cases of fibromyalgia and CFS cannot just be rejected solely for lack of traditional objective findings.

    We hope you find this summary useful as you record your observations, so your patients who qualify for Social Security disability may present the necessary medical documentation. The case study belongs to Social Security Disability Lawyer Articles.

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  • Study shows that Fibromyalgia (FM) and Irritable Bowel Syndrome (IBS) mostly attack together

    Study shows that Fibromyalgia (FM) and Irritable Bowel Syndrome (IBS) mostly attack together

    Len Chung, MD Associate Professor of Medicine, Co-Director of the UCLA/CURE Neuroenteric Disease Program, Director of the UCLA Motility Unit Irritable bowel syndrome (IBS) is a very common gastrointestinal condition, which is present in 8- 20% of the general population.

    Several population-based studies have demonstrated IBS symptoms to be more common in women, with prevalence ratios ranging from 2 to 3:1. It has been estimated to affect 14-24% of women and 5-19% of men. The classic gastrointestinal symptoms of IBS are chronic or recurrent abdominal pain and/or discomfort and associated alterations in bowel habits.

    However, many individuals with IBS also suffer from non-gastrointestinal symptoms. Rheumatologic symptoms, such as skin rashes, muscle contraction headache, and myalgias, have been reported in two-thirds of IBS patients. Previous studies have found that IBS typically overlaps with fibromyalgia syndrome (FM) in the same patient, suggesting a common cause.

    FM occurs in up to 60% of patients with irritable bowel syndrome (IBS). Up to 70% of patients with a diagnosis of FM have symptoms of IBS. FM belongs to a general class of chronic musculoskeletal pain syndromes. It is a common pain disorder in which the presence of multiple muscular tender points is associated with characteristic symptoms of generalized muscle aching, stiffness, fatigue, and an abnormal sleep pattern.

    Following osteoarthritis and rheumatoid arthritis, FM is the most common disorder seen in community rheumatologic practice. In rheumatology clinics, the proportion of new patients with FM syndrome ranges from 10% to 20%, while in non-specialized settings, the reported prevalence is less, 2.1% to 5.7%. FM affects 2% for both sexes, 3.4% for women and 0.5% for men.

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    The diagnosis of FM is presently defined by criteria, which consists of widespread pain and the presence of painful tender points established by the American College of Rheumatology in 1990. Although IBS is a chronic gastrointestinal pain condition and FM is a chronic muscular pain disorder, IBS and FM have common clinical characteristics:

    • both are functional pain disorders which cannot be explained by structural or biochemical abnormalities,
    • both occur predominantly in women,
    • the majority of patients associate stressful life events with the onset or exacerbation of symptoms,
    • the majority of patients complain of disturbed sleep and fatigue,
    • psychotherapy and behavioral therapies are efficacious in treating symptoms,  
    • certain medications can treat symptoms of both conditions.

    It has been suggested that IBS and FM have a common cause and that specific physiologic alterations may be responsible for the symptoms seen in these two conditions. While IBS is a condition characterized by visceral (intestinal) hypersensitivity, FM is a condition of somatic (skin and muscle) hypersensitivity.

    There have been several studies, which have shown that IBS patients have normal or decreased somatic sensitivity. We have recently completed somatic perception studies in female patients with IBS alone, both IBS + FM, and healthy individuals.

    The response to pressure that was placed on particular muscle tender points was measured. Like FM patients, patients with IBS + FM demonstrate somatic hyperalgesia (increased somatic pain sensation). However, patients with IBS alone have somatic hypoalgesia (decreased somatic pain sensation).

    This study demonstrates that while IBS patients have increased sensitivity to visceral pain, they are less sensitive to somatic pain. Only a couple of studies have evaluated visceral sensation in FM patients using a balloon catheter placed in the rectum and lower large intestine (colon).

    The balloon catheter is connected to a computerized pump which inflates the balloon and thus reaches specific pressure levels in the bowel. The patient’s sensations in response to the balloon inflation can be measured. These studies have reported that patients with FM with or without IBS have visceral perception in between that of healthy controls and IBS patients.

    These data suggest that IBS has altered perceptual responses to visceral and somatic pain/discomfort and the coexistence of FM alters these perceptual responses. Recent studies using brain-imaging techniques have found alterations in how the brain processes visceral information in IBS.

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    To determine if similar altered responses to visceral and somatic pain information occur in patients with IBS and FM, we have compared the brain responses to visceral and somatic stimuli in patients with IBS alone, IBS + FM, and healthy individuals. Brain responses are assessed by positron emission tomography (PET), which can measure blood flow to brain areas in response to a particular stimulus.

    Results have shown that patients with both IBS and FM have greater brain responses in areas that are involved in pain, memory retrieval of past painful experiences, and increased attention or awareness to a stimulus than the other subject groups. Recent functional brain imaging studies have suggested that alterations in the processing of sensations by the brain play an important role in IBS and FM.

    In summary, clinical characteristics and significant overlap of symptoms suggest that the functional syndromes IBS and FM may have a common etiology. Visceral and somatic perception studies and brain imaging have demonstrated that each of these conditions has specific responses to painful stimuli and that patients with both IBS and FM may have responses to somatic and visceral stimuli that are uniquely different from that of IBS alone and FM alone.

    Further studies are being performed in these common conditions to further our understanding of chronic visceral and somatic pain conditions and lead to more effective treatment.

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  • My Wrist has Stuck due to Fibromyalgia Pain

    My Wrist has Stuck due to Fibromyalgia Pain

    Wrist Stuck is a condition that typically involves fibromyalgia pain. This fibro wrist stuck diagnosis can have many different manifestations. The fibromyalgia wrist stuck is generally considered to be centered around a heightened sensitivity of the veins system stuck, especially in the arm pain. Many people with fibromyalgia experience multiple wrist symptoms including:

    The wrist symptom that most people have in common is stuck pain. This wrist pain can affect many parts of the body, including any part of the arm.

    Fibromyalgia Wrist Stuck symptoms causes

    While the cause of wrist stuck in fibromyalgia is not yet fully understood, many theories about the condition include its onset being triggered by different stressors. These triggers may include mental stress, having weight lifting causes, and other general medical health problems.

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    Fibromyalgia wrist stuck signs and symptoms

    The main symptom leading to a diagnosis of fibromyalgia wrist stuck is damaged veins pain. While all-over pain is common, the pain can also be more localized. It can be located exactly in the wrist joint of occasional or constant.

    Other symptoms, such as numbness and tingling with fibromyalgia are also caused by wrist stuck, may be confused with veins damage conditions that affect the arms and hands. Often, the numbness and tingling of fibromyalgia are not to the same degree as we see with other veins damage conditions in the arm. It also does not always follow the typical patterns of veins and nerves in the limb.

    Therefore, a careful sensory exam is needed to help find the actual cause of hand numbness or tingling. Special nerve testing (EMG/NCV) can help to clarify the causes of the wrist stuck symptoms in the elbow, forearm, or hand and can help determine whether the symptoms are coming from veins and nerve problems.

    There are no common tests, such as x-rays or blood studies, to diagnose fibromyalgia wrist stuck pain, or the disease in general. The diagnosis is made primarily by physical examination and a review of all fibromyalgia arm symptoms (movement pain, weight lifting, veins damage, mental stress, sleepy hand problems, mental fogginess, arthritis problems, etc.).

    The diagnosis can be confusing because people with stuck wrist fibromyalgia can also have other conditions in the arm which are unrelated to the fibromyalgia diagnosis, such as carpal tunnel syndrome.

    Fibromyalgia wrist stuck treatments

    There are no surgical treatments for wrist stuck in fibromyalgia hand pain or arm pain, but other conditions present at the same time may benefit from surgical treatment.

    Arthritis specialists (rheumatologists) may assist with the diagnosis and management of wrist stuck in fibromyalgia. They may recommend medications, activity/exercises changes, and other treatments to help with the symptoms of wrist stuck in fibromyalgia.

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  • Hallmarks of Fibromyalgia Ankle Pain and its Causes

    Hallmarks of Fibromyalgia Ankle Pain and its Causes

    You love your morning jogs. Watching the sunrise as the wind blows through your hair seems to center you for the day. But one day, your foot lands strangely slips out from under you, and you’re stuck on the sidewalk with a fibromyalgia ankle that’s just not right.

    Are you rankled by fibromyalgia ankle pain symptoms? Fibromyalgia Ankle pain can be felt on the inner side of the ankle, on the outer area, in line with the Achilles tendon, and sometimes radiating near the upper part of the foot.

    Common characteristics and accompanying symptoms of fibromyalgia ankle pain

    If you’re experiencing ankle pain, it is also likely to experience:

    • Burning pain in the ankle: While walking, jogging, and running
    • Swelling of the ankle
    • Redness
    • Bruising
    • Numbness or tingling sensation
    • Inability to bear weight on the ankle
    • Stiffness
    • Weakness

    Fibromyalgia causes severe ankle pain

    Severe Fibro ankle pain can usually be described by the following details.

    • Pain: Sudden, severe pain that makes it all but impossible to walk.
    • Obvious deformity: The ankle appears crooked or misshapen, or there may be bone protruding through the skin.
    • Swelling
    • Ankle bruising
    • Ankle redness and heat

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    The fibromyalgia ankle is a tricky little thing. It also bears plenty of your body’s weight. Its health and ability to function are crucial to everyday activities and comfort.

    The ankle is an important joint, connecting the lower leg bones to the foot bones. It is divided into the lower ankle and upper ankle. The lower ankle allows your foot to tilt to the side and turn outwards and inwards. The upper ankle lets you move your feet up and down.

    Whether you injure the joint, a bone, the upper ankle, or the lower, the associated fibromyalgia pain can literally stop you in your tracks. Most causes of ankle pain are treatable though. With a little time, you can be back to your normal activities.

    Duration of symptoms

    The duration of your ankle pain may vary depending on the cause.

    • Acute: Severe fibromyalgia ankle pain almost always starts suddenly, usually as the result of an injury.
    • Chronic: A chronic ankle condition can become acute if the disease causing it worsens, or there is wear-and-tear after an old injury and the damage suddenly gives way.

    Who is most often affected with fibromyalgia ankle pain?

    People most likely to experience severe fibromyalgia ankle pain include the following:

    Is severe fibromyalgia ankle pain serious?

    Fibro Ankle pain that is described as severe will likely require a consult with your physician if it persists.

    • Not serious: The pain subsides quickly after the fibromyalgia injury and any swelling responds to rest, ice, and over-the-counter non-steroidal anti-inflammatory drugs.
    • Moderately serious: The fibromyalgia ankle pain continues for a few days, even without signs of fracture or infection.
    • Serious: If there is fibromyalgia ankle pain along with an obvious injury or deformity, and/or redness and swelling in the ankle, this is a medical emergency.

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  • How do Breastfeeding Moms Tackle Fibromyalgia?

    How do Breastfeeding Moms Tackle Fibromyalgia?

    Relaxation can help in Breastfeeding

    Breastfeeding may sound like the most natural thing in the world, but many women find it harder than expected. Mothers with fibromyalgia often have an especially tough time with breastfeeding, according to a new study.

    Fibromyalgia is a chronic disorder characterized by widespread pain and fatigue. Its cause is not known, and it affects more women than men.

    There is no cure for fibromyalgia. Patients often try physical therapy, counseling, and medication (including antidepressants, ibuprofen, and in some cases, morphine) for symptom relief.

    Karen Schaefer, DNSc, RN, assistant professor of nursing at Temple University’s College of Health Professions, studied nine mothers aged 26-36 with fibromyalgia.

    All of the women wanted to breastfeed and had birthed at least one baby before being diagnosed with fibromyalgia. Most had taken medication for their fibromyalgia before pregnancy.

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    Problems Reported

    Breastfeeding was not easy for any of the mothers in the study.

    “All nine women felt that they were not successful in their attempts to breastfeed, and felt frustrated,” Schaefer writes.

    Difficulties included muscle soreness, pain, and stiffness; fatigue; a perceived shortage of breast milk; and sore nipples.

    Those problems are not uncommon among breastfeeding women. However, mothers with fibromyalgia may be particularly affected since they already face pain and fatigue.

    The problems were bad enough that some participants felt they needed to resume medication, which meant giving up breastfeeding to avoid passing the drugs to the babies through breast milk.

    Others stopped breastfeeding after being diagnosed with other health problems, such as hypothyroidism or hepatitis B.

    Feeling “forced” to wean their babies earlier than planned, the mothers were sad and depressed, Schaefer writes.

    Supportive Strategies

    Mothers with fibromyalgia may want to try breastfeeding tips noted in the study:

    • Enlist support. Ask friends and family members for encouragement and assistance.
    • Seek expert help. Ask lactation consultants or nurses for advice. Pregnant women with fibromyalgia may want to start preparing before delivery.
    • Delegate other tasks. Save as much energy as possible for infant care and breastfeeding.
    • Pay attention to proper nutrition.
    • Try relaxation techniques and music therapy to promote relaxation and reduce discomfort during breastfeeding.
    • Find a support group for breastfeeding mothers with chronic illnesses.
    • When breastfeeding, lie on one side with a pillow supporting the woman’s head.
    • Change positions while breastfeeding.
    • Use a sling or some type of support, such as a pillow, under the baby.
    • Find a quiet, restful place to feed the baby to reduce distractions for yourself and your baby.

    Schaefer also encourages healthcare providers to proactively support moms with fibromyalgia who want to breastfeed.

    The study appears in The American Journal of Maternal/Child Nursing.

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  • Is there a potential cure for fibromyalgia or a way to protect against fibromyalgia?

    Is there a potential cure for fibromyalgia or a way to protect against fibromyalgia?

    Fibromyalgia is primarily a neurological brain disorder. It is seven times more likely to strike women than men, and it doesn’t matter what nationality you are. The hypothalamus part of the brain acts as a circuit breaker/fuse box for the rest of the brain and body. It’s like the battery for the entire body.

    There are several things that typically cause Fibromyalgia and Chronic Fatigue Syndrome to manifest, but basically high amounts of stress are what cause the hypothalamus to blow its fuse, creating a host of neurological problems, like hormone imbalances, increased pain sensitivity, fatigue, and “brain fog“. Essentially, you’ve got a dead battery that won’t hold a charge, which is why so many people experience debilitating fatigue. The blown fuse can happen in an instant, and you get no say in if or when it happens.

    The hypothalamus has done a system-wide “shutting down” and tried to reboot, in an effort to protect your body and brain from further stress and damage. Like when you turn off your computer and restart it because using Ctrl +Alt +Delete hasn’t worked. Only, by doing this, the brain is permanently altered, like a computer virus that can’t be repaired.

    A person can quite literally be fine one day and wake up the next morning feeling so completely different, and your entire life has changed because your brain no longer functions the way it used to. Many Fibro/CFS patients can pinpoint the exact day/week/month everything changed for them. The most common “triggers” fibromyalgia patients report are:

    A virus/illness or a prolonged decrease in the immune system
    Lime’s Disease, Epstein Bar Virus, Mono are often associated with the development of Fibromyalgia and CFS symptoms. etc.

    A sudden traumatic event
    A house fire, abusive situations, physical attacks, etc. Similar to PTSD, or Dissociation disorders, the brain is trying to cope and process the additional shock and stress, triggering the hypothalamus to “protect” the rest of the brain by flipping a switch.

    An accident
    Car accidents, drowning, severe falling, etc. can cause the hypothalamus to be trying to “protect” by flipping the switch.

    Medical or dental surgery
    Any time you have surgery, it puts the body under huge increases in stress, because cutting into your body sends the brain “we are under attack!” signals.

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    Pregnancy
    Because of the drastic hormonal shifts, joint stress, depleted vitamins and minerals, and the physical trauma of the birth process, pregnancy creates so much stress that for whatever reason the mother’s body just can’t handle it. Fibromyalgia develops during pregnancy or soon after birth. For many women, their Fibromyalgia symptoms and Chronic Fatigue are ignored as simple “hormone shifts” or ” new mommy fatigue”, when in fact her body will never really readjust back to normal.

    High-pressure lifestyles/stressful jobs/major anxiety
    Workaholics, or people who don’t take enough time off, or just can’t relax and rest. In school-age students, the stress of studies, trying to get good grades, fears of the future, or even too many activities can cause an abundance of stress the body can’t handle.

    For some adults, this means they get sick in the form of common things like high blood pressure, heart attacks, or stroke. Others can develop Fibromyalgia and Chronic Fatigue Syndrome, or other random “stress-related” illnesses.

    Many people are able to live completely normal, energetic, and happy lives BEFORE these stressful, triggering events. Any of these things can cause the hypothalamus fuse to blow like a light bulb that goes out. Once that fuse blows, basically your “brain is broken“. It doesn’t matter how old you are, or what gender. Even children and teenagers can (and do) develop Fibro and CFS, especially if they have had an accident, undergone serious trauma, or had to have surgery. Being young doesn’t automatically mean someone is healthy, even if they “look healthy”.

    This can happen to anyone, at any time, and once it does, there is no way to change that. You can’t just flip the switch back to fix it. The hypothalamus begins sending the wrong signals to the rest of the brain and to the nerves, causing the super sensitive fascia, painful joints and muscles, sensitivity to touch, and intolerance to certain foods and weather changes, causing thyroid and metabolic changes, and cognitive disruptions.

    Ironically, the brain’s fuse box blows in an effort to protect your brain and body from further damage because of the prolonged stress you have already been under. This is the chief reason why so many Fibromyalgia patients experience a “Flair Up” of pain and other symptoms when they are under high amounts of additional life stress, like family conflict or having to pack and move. Things like exercise and many mundane physical activities are just too stressful for an already constantly stressed out body, so these things cause a flair-up of symptoms.

    The body is already so stressed out from whatever life has thrown at you and being in pain 24/7 that you just can’t handle it anymore. The “Flare Up” will force you to slow down and rest, even when you have things you need to do. This is why a Fibro/CFS patient can feel okay enough to go out and do things one day (feeling “normal“) and be utterly exhausted for the days or weeks after, in a “Flair up”.

    Because Fibromyalgia is so physically debilitating, in this way your body is forcing you to rest and slow down, so it can make an effort to heal itself and relax. This is why people with Fibro need to take steps to simplify their life and be as stress-free as possible. Medicine and Science is just now figuring this out, and it might take another couple of decades for them to agree on a treatment plan that will actually cure the hypothalamus and flip the switch back on.

    Please note that this is an extremely simplified explanation of brain functions and responses. There has been tons of research by the medical community that can go into even greater details. I simply tried to put my understanding of their complex (and complicated) research discoveries into common terms and phrases people can easily relate to. I am not a doctor, but I have spent the last decade researching and learning about my diagnosis.

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    References:

    Fibromyalgia Contact Us Directly

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    Official Fibromyalgia Blogs

    Click here to Get the latest Chronic illness Updates

    Fibromyalgia Stores

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  • What is FibroCovid? Almost one-third of Patients in the Italian Study had Musculoskeletal Sequelae

    What is FibroCovid? Almost one-third of Patients in the Italian Study had Musculoskeletal Sequelae

    Among patients who developed post-acute COVID-19 — so-called “long COVID” — almost one-third reported clinical features of fibromyalgia, Italian researchers reported.

    In a web-based survey that included more than 600 patients, 30.7% met the American College of Rheumatology criteria for a fibromyalgia diagnosis at a mean of 6 months after having had COVID-19, said Francesco Ursini, MD, Ph.D., of the University of Bologna, and colleagues.

    “In light of the overwhelming numbers of the SARS-CoV-2 pandemic, it is reasonable to forecast that rheumatologists will face a sharp rise in cases of a new entity that we defined as ‘FibroCOVID,’”

    Aside from the potentially lethal acute viral infection of SARS-CoV-2, a post-acute syndrome with myriad symptoms including not only pulmonary sequelae but also endocrine, cardiovascular, neuropsychiatric, and musculoskeletal manifestations is now widely recognized.

    The current definition of fibromyalgia requires a score of 13 or higher on the Fibromyalgia Symptom Scale, which combines scores on the Widespread Pain Index and Symptom Severity Scale.

    The pathogenesis of fibromyalgia is not completely understood. “Pain augmentation/dysperception seems associated with exquisite neuron morphological modifications and imbalance between pronociceptive and antinociceptive pathways arising from an intricate interplay between genetic predisposition, stressful life events, psychological characteristics, and emerging peripheral mechanisms, such as small fiber neuropathy or neuroinflammation,” Ursini and colleagues explained.

    In addition, viral triggers have been linked with the development of fibromyalgia. Therefore, to investigate the prevalence of fibromyalgia following acute COVID-19, the researchers conducted a cross-sectional survey during April 2021, in which participants completed a survey that included information on demographics, symptoms, and duration of COVID-19, and comorbidities.

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    A total of 616 patients were included, with 189 diagnosed with fibromyalgia. More than three-quarters were women whose mean age was 45. The median duration of acute COVID-19 was 13 days, and 10.7% were hospitalized. Among the symptoms reported during the acute viral illness were anosmia/ageusia in 70.9%, myalgia in 70.4%, fever in 67.7%, and arthralgia in 64.6%.

    Comorbidities included anxiety and chronic pulmonary disease in patients both with and without fibromyalgia. In contrast, hypertension was significantly higher among fibromyalgia patients (27% vs 10.8%, P<0.0001), as was the mean body mass index (30.4 vs 23, P<0.0001) and the prevalence of obesity (49.2% vs 2.1%, P<0.0001).

    Among the survey respondents who had fibromyalgia, 57% were women, a percentage that was lower than the 77.4% of women in the cohort overall, suggesting that men more often developed the musculoskeletal sequelae, the researchers explained.

    Those with fibromyalgia also were significantly more likely to be hospitalized (19% vs 7%, P<0.0001). During the acute phase of the disease, patients who subsequently developed fibromyalgia more often reported cough (52.9% vs 45%, P=0.046) and dyspnea (45.5% vs 35.4%, P=0.017), and also more often required supplemental oxygen (18% vs 7.5%, P<0.0001).

    On univariate analysis, factors associated with fibromyalgia included age, male sex, cough, dyspnea, hypertension, obesity, and treatment with antibiotics, low molecular weight heparin, or oxygen.

    On multivariate analysis, the only independent predictors were male sex, with an odds ratio of 9.951 (95% CI 6.025-16.435, P<0.0001) and obesity, with an odds ratio of 82.823 (95% CI 32.192-213.084, P<0.0001).

    Overall, patients who developed fibromyalgia appeared to have a more serious phenotype of COVID-19, more often requiring hospitalization and supplemental oxygen, the researchers reported. “Notably, both male gender and obesity have been consistently associated with a more severe clinical course in patients with COVID-19, including a significantly increased mortality rate.”

    Potential mechanisms by which the coronavirus could trigger fibromyalgia, the team speculated, are epithelial injury or damage to the neuromuscular, immune dysfunction, and upregulation of inflammatory cytokines such as interleukins 1 and 6.

    Prospective studies will be needed to further elucidate the clinical course and outcomes of the post-acute COVID-19 musculoskeletal disease manifestations, the authors cautioned.

    A potential limitation of the study, they said, was the possibility of self-selection bias.

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  • Pleasure, pain brain signals disrupted in fibromyalgia patients

    Pleasure, pain brain signals disrupted in fibromyalgia patients

    New research indicates that a disruption of brain signals for reward and punishment contributes to increased pain sensitivity, known as hyperalgesia, in fibromyalgia patients. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggest that this altered brain processing might contribute to widespread pain and lack of response to opioid therapy in patients with fibromyalgia.

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    Fibromyalgia is a chronic, musculoskeletal syndrome characterized by widespread joint and muscle pain along with other symptoms such as fatigue, sleep disturbances, and cognitive difficulty. Previous research estimates that fibromyalgia affects 3.4% of women and 0.5% of men in the U.S. Prevalence of this pain disorder increases with age, affecting more than 7% of women between 60 and 79 years of age.

    “In patients with fibromyalgia there is an alteration in the central nervous system pain processing and a poor response to topical pain treatments, trigger point injections and opioids,” said lead author Dr. Marco Loggia from Massachusetts General Hospital and Harvard Medical School in Boston. “Our study examines the disruption of brain function involved in the individual experience of pain anticipation and pain relief.”

    For the present study, the research team enrolled 31 patients with fibromyalgia and 14 healthy controls. Functional magnetic resonance imaging (MRI) and cuff pressure pain stimuli on the leg were performed on all subjects. During the MRI, participants received visual cues alerting them of impending pain onset (pain anticipation) and pain offset (relief anticipation).

    Results show that during pain anticipation and relief, fibromyalgia patients displayed less robust response within brain regions involved in sensory, affective, cognitive and pain regulating processes. The ventral tegmental area (VTA) — a group of neurons in the center of the brain involved in the processing of reward and punishment — displayed activation during pain anticipation and stimulation, but deactivation during anticipation of relief in healthy controls. In contrast, VTA responses during periods of pain, and anticipation of pain and relief, in fibromyalgia patients were significantly reduced or inhibited.

    Dr. Loggia concludes, “Our findings suggest that fibromyalgia patients exhibit altered brain responses to punishing and rewarding events, such as expectancy of pain and relief of pain. These observations may contribute to explain the heightened sensitivity to pain, as well as the lack of effectiveness of pain medications such as opioids, observed in these patients. Future studies should further investigate the neurochemical basis underlying these dysfunctions.”

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  • Young people report worse fibromyalgia than older patients

    Young people report worse fibromyalgia than older patients

    It may seem counterintuitive, but young and middle-aged fibromyalgia patients report worse symptoms and poorer quality of life than older patients, a Mayo Clinic study shows. Fibromyalgia most often strikes women. It is characterized by widespread musculoskeletal pain with fatigue, sleep, memory and mood issues. The research, one of several Mayo studies being presented at the American College of Rheumatology annual meeting, suggests the disorder plays out differently among different age groups.

    Researchers studied 978 fibromyalgia patients and divided them into three age groups: those 39 or younger, those 50 to 59, and those 60 or older. The younger and middle-aged patients were likelier to be employed, unmarried, smokers and have a higher education level, lower body mass index, more abuse history and a shorter duration of fibromyalgia symptoms than older patients.

    “Among the three age groups of young, middle-aged and older, symptom severity and quality of life differs,” says senior author Terry Oh, M.D., a physical medicine and rehabilitation physician at Mayo Clinic in Rochester, Minn. The study’s findings were surprising, because quality of life and physical health are considered to be negatively associated with age, Dr. Oh says.

    Dr. Oh notes that women in all three groups with fibromyalgia reported a lower quality of life than average U.S. women, and that the difference between their physical health and that of the average woman was more significant than mental health differences, particularly in young patients.

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    In other studies, Mayo researchers found:

    *About 7 percent of fibromyalgia patients had inflammatory rheumatic conditions, and that in general, those fibromyalgia patients didn’t do as well with treatment as those without rheumatic diseases.

    *Fibromyalgia patients may also have skin-related symptoms such as excessive sweating or burning or other sensations.

    *Obese patients with polymyalgia rheumatica have more pain and disability than other polymyalgia rheumatica patients. They also tend to need higher doses of glucocorticoids.

    *Rheumatoid arthritis patient experiences and symptoms do not always reflect what medical literature shows when it comes to pain, morning stiffness, the relationship between swelling and damage, and what worsens or improves symptoms.

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    *Hospitalization is a significant risk factor for gout flares in people already diagnosed with gout.

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  • Discovery could eventually help diagnose and treat chronic pain

    Discovery could eventually help diagnose and treat chronic pain

    More than 100 million Americans suffer from chronic pain. But treating and studying chronic pain is complex and presents many challenges. Scientists have long searched for a method to objectively measure pain and a new study from Brigham and Women’s Hospital advances that effort. The study appears in the January 2013 print edition of the journal Pain.

    “While we need to be cautious in the interpretation of our results, this has the potential to be an exciting discovery for anyone who suffers from chronic pain,” said Marco Loggia, PhD, the lead author of the study and a researcher in the Pain Management Center at BWH and the Department of Radiology at Massachusetts General Hospital. “We showed that specific brain patterns appear to track the severity of pain reported by patients, and can predict who is more likely to experience a worsening of chronic back pain while performing maneuvers designed to induce pain. If further research shows this metric is reliable, this is a step toward developing an objective scale for measuring pain in humans.”

    Specifically, researchers studied 16 adults with chronic back pain and 16 adults without pain and used a brain imaging technique called arterial spin labeling to examine patterns of brain connectivity (that is, to examine how different brain regions interact, or “talk to each other”). They found that when a patient moved in a way that increased their back pain, a network of brain regions called Default Mode Network exhibited changes in its connections. Regions within the network (such as the medial prefrontal cortex) became less connected with the rest of the network, whereas regions outside the network (such as the insula) became connected with this network. Some of these observations have been noted in previous studies of fibromyalgia patients, which suggests these changes in brain connectivity might reflect a general feature of chronic pain, possibly common to different patient populations.

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    “This is the first study using arterial spin labeling to show common networking properties of the brain are affected by chronic pain,” said study author Ajay Wasan, MD, MSc, Director of the Section of Clinical Pain Research at BWH. “This novel research supports the use of arterial spin labeling as a tool to evaluate how the brain encodes and is affected by clinical pain, and the use of resting default mode network connectivity as a potential neuroimaging biomarker for chronic pain perception.”

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